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Korean Journal of Obstetrics & Gynecology 2001;44(4):663-667.
Published online April 1, 2001.
Dectection of Ureaplasma urealyticum in Invasive Cervical Cancer Tissue.
Un Mo Ahn, Nam Won Seo, Do Hyung Kim, Tae Hong Yeo, Tae Kyoung Kang, Jun Hong Kim, Sunn Ie Ahn, Dong Hwi Kim, Un Dong Park
Department of Obstetrics and Gynecology, College of Medicine, University of Kosin, Pusan, Korea.
Abstract
OBJECTIVE
Mycoplasmas have been implicated in many diseases including cervicitis, urethritis, salpingitis, endometritis... and functioning as cofactors catalyzing the HIV disease state. The oncogenic potentiality of mycoplasma was only recently realized when they were shown causing chromosomal changes and in vitro cell transformations through gradual progressive chromsomal loss and translocation. Few study has been reported the prevalence of mycoplasma infection in human cancers and suggested that there was a connection between these organisms and human cancers. The objective of this study was to determine the relationship between Ureaplasma urealyticum infection and cervical cancer. METHODS: The detection frequency of Ureaplasma urealyticum in 52 invasive cervical cancer tissues and 17 normal cervical tissues was studied using PCR. RESULTS: U. urealyticum DNA was detected in 8 out of 52(15.4%) invasive cervical cancer tissues and 1 out of 17(5.9%) normal cervical tissues. No statistic significance was observed between the detection frequency of Ureaplasma urealyticum and clinicopathologic parameters. The prevalence of Ureaplasma urealyticum in invasive cervical tissues was 15.4% and this rate was higher than 5.9% in normal cervical tissues but there was no statistic significance. CONCLUSIONS: With respect to clinicopathologic parameters of cervical cancer, there was no significant relation between U. urealyticum infection and cervical cancer. There is, however, few study and case on cervical cancer internally and externally. It is considered that more studies on the subject with much cases should be made.
Key Words: Mycoplasma, Oncogenesis, Ureaplasma urealyticum, cervical cancer, PCR


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