| Insulin-like growth factor-I and II and insulin-like growth factor binding protein-3 in amniotic fluid at second trimester: A correlation with birth weight. |
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Ji Young Kim, Soon Ha Yang, In Sik Lee |
1Department of Obstetrics and Gynecology, School of Medicine, Sungkyunkwan University, Samsung Medical Center.
2Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. |
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| Abstract |
OBJECTIVE
o determine the correlation between birth weight and the level of insulin-like growth factor(IGF)-I, -II and insulin-like growth factor binding protein(IGFBP)-3 in amniotic fluid at second trimester and to evaluate possibility whether the levels of IGF-I, II and IGFBP-3 could predict birth weight. METHODS: Sixty-seven samples of amniotic fluid in second trimester were analyzed for IGF-I, IGF-II, and IGFBP-3 by radioimmunoassay. Newborn birth weights were stratified arbitrarily as <25th percentile, 25-75th percentile, and >75th percentile. Linear regression analysis and Kruskal-Wallis test were used in well appropriately for statistical analysis. RESULTS: The level of IGF-I showed positive correlation with birth weight. However, the levels of IGF-II and IGFBP-3 showed no significant correlation with birth weight. The level of IGF-I were signifi cantly different among these groups. However, the levels of IGF-II and IGFBP-3 were not significantly different among these groups divided by the birth weight percentile. CONCLUSION: The levels of IGF-I in amniotic fluid at second trimester may be useful marker in predicting birth weight. |
| Key Words:
Insulin-like growth factor, Insulin-like growth factor binding protein, Amniotic fluid, Birth weight |
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