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Korean Journal of Obstetrics & Gynecology 2001;44(4):668-673.
Published online April 1, 2001.
Insulin-like growth factor-I and II and insulin-like growth factor binding protein-3 in amniotic fluid at second trimester: A correlation with birth weight.
Ji Young Kim, Soon Ha Yang, In Sik Lee
1Department of Obstetrics and Gynecology, School of Medicine, Sungkyunkwan University, Samsung Medical Center.
2Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
Abstract
OBJECTIVE
o determine the correlation between birth weight and the level of insulin-like growth factor(IGF)-I, -II and insulin-like growth factor binding protein(IGFBP)-3 in amniotic fluid at second trimester and to evaluate possibility whether the levels of IGF-I, II and IGFBP-3 could predict birth weight. METHODS: Sixty-seven samples of amniotic fluid in second trimester were analyzed for IGF-I, IGF-II, and IGFBP-3 by radioimmunoassay. Newborn birth weights were stratified arbitrarily as <25th percentile, 25-75th percentile, and >75th percentile. Linear regression analysis and Kruskal-Wallis test were used in well appropriately for statistical analysis. RESULTS: The level of IGF-I showed positive correlation with birth weight. However, the levels of IGF-II and IGFBP-3 showed no significant correlation with birth weight. The level of IGF-I were signifi cantly different among these groups. However, the levels of IGF-II and IGFBP-3 were not significantly different among these groups divided by the birth weight percentile. CONCLUSION: The levels of IGF-I in amniotic fluid at second trimester may be useful marker in predicting birth weight.
Key Words: Insulin-like growth factor, Insulin-like growth factor binding protein, Amniotic fluid, Birth weight


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