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Korean Journal of Obstetrics & Gynecology 2001;44(4):727-733.
Published online April 1, 2001.
An Immunohistochemical study on the Expression of EGFR, TGF-alpha and Ki-67 in the Uterine Cervical Neoplasia.
Jib Kwang Chung, Seul Kee Lee, Min Kwan Kim, Dong Han Bae, Chang Jin Kim
1Department of Obstetrics and Gynecology College of Medicine, Soonchunhyang University, Chunan, Korea.
2Department of Pathology College of Medicine, Soonchunhyang University, Chunan, Korea.
Abstract
OBJECTIVE
Cervical carcinoma of the uterus, the most common maliganacy among women in Korea, which its etiology and pathogenesis are not yet determined. Recently, since it has been found about the function of the growth factor and its receptor, involved in the regulation of cellular growth and differentiation, many studies have been undertaken about the role of growth factors and its receptors in the growth and differentiation of the tumor cell. METHODS: In this study, we examined the expression of EGFR, TGF-alpha and Ki-67 in 50 CINs and 20 invasive cervical cancers using immunohistochemical stain. RESULTS: Positive rate of EGFR was 92% in CIN, 80% in invasive cancer, negative rate of TGF-alpha was 74% in CIN, 80% in invasive cancer and Ki-67 labelling index(LI) in normal basal cell, CIN I-II, CIN III were 5+/-0.7, 13+/-2.5, 65+/-5.4 repectively and in invasive cancer, LI was over 90. from this result as cervical carcinoma progresses, the expression of EGFR and Ki-67 increase while that of TGF-alpha decreases. CONCLUSION: As cervical carcinoma progress, the expression of EGFR and Ki-67 increase while that of TGF-alpha decreases. Further studies on the expression of EGFR and TGF-alpha and its growth-stimulation mechanism in cervical carcinoma are warranted to establish the pathogenesis of the cervical carcinoma.
Key Words: EGFR, TGF-alpha, Ki-67, CIN, Invasive cervical cancer


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