Increase of breast parenchymal density during hormone replacement  therapy in postmenopausal women.

Jee, Byung Chul

Original Article

Korean Journal of Obstetrics & Gynecology 2001;44(5):867-871.
Published online May 1, 2001.

Increase of breast parenchymal density during hormone replacement therapy in postmenopausal women.

¹Department of Obstetrics and Gynecology, College of Medicine, Cheju National University, KOREA.
²Department of Diagnostic Radiology, Cheju Medical Center, Cheju, KOREA.

Abstract

PURPOSE
To verify the increase of mammographic density in women with 1-year hormone replacement therapy(HRT). METHODS: A total of 53 HRT users who received same HRT regimen during 1 year with a normal baseline mammogram and 1-year follow-up mammogram was recruited. Seventy-three never-users were allocated as control group. RESULTS: The increase of mammographic density was observed in 22.6% of 1-year HRT users, compared with 6.8% in never-users (P=0.023). The odds ratio was 3.98 (95% CI : 1.31~12.1) in 1-year HRT users, and 8.37 (95% CI : 2.36~29.6) in continuous combined regimen group compared to control. CONCLUSION: The incidence of dense mammogram was significantly higher in women with 1-year HRT users than in control, and the risk was remarkable in continuous combined regimen group.

Key Words: hormone replacement therapy, mammographic density