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Korean Journal of Obstetrics & Gynecology 2001;44(5):867-871.
Published online May 1, 2001.
Increase of breast parenchymal density during hormone replacement therapy in postmenopausal women.
Byung Chul Jee
1Department of Obstetrics and Gynecology, College of Medicine, Cheju National University, KOREA.
2Department of Diagnostic Radiology, Cheju Medical Center, Cheju, KOREA.
Abstract
PURPOSE
To verify the increase of mammographic density in women with 1-year hormone replacement therapy(HRT). METHODS: A total of 53 HRT users who received same HRT regimen during 1 year with a normal baseline mammogram and 1-year follow-up mammogram was recruited. Seventy-three never-users were allocated as control group. RESULTS: The increase of mammographic density was observed in 22.6% of 1-year HRT users, compared with 6.8% in never-users (P=0.023). The odds ratio was 3.98 (95% CI : 1.31~12.1) in 1-year HRT users, and 8.37 (95% CI : 2.36~29.6) in continuous combined regimen group compared to control. CONCLUSION: The incidence of dense mammogram was significantly higher in women with 1-year HRT users than in control, and the risk was remarkable in continuous combined regimen group.
Key Words: hormone replacement therapy, mammographic density


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