Korean J Obstet Gynecol Search


Korean Journal of Obstetrics & Gynecology 2001;44(5):904-910.
Published online May 1, 2001.
Alterations in substance P and CGRP immunoreactivities in the uterus following the induction of inflammation in the rats.
Joong Yol Na, Ki Hoon Chang, Sang Wook You, Soon Choul Hong, Seo Eun Lee, Hee Chul Han
1Department of Obstetrics and Gynecology, College of Medicine, Korea University, Seoul, Korea.
2Department of Physiology, College of Medicine, Korea University, Seoul, Korea.
Recently some reports suggested substance P and CGRP might be important factors for inflammation and hyperalgesia. This study was performed to see whether substance P or CGRP containing nerve fibers might be changed by mustard oil-induced inflammation. METHODS: After injection of mustard oil(5%) into uterine lumen, the uteri were removed and examined with immunohistochemical methods for substance P and CGRP. RESULTS: In the normal uterus, most of the substance P- or CGRP-immunoreactive nerve fibers were observed along the vascular structure and some in the myometrium, only few in the endometrium. Mustard oil did not changed this pattern of nerve fiber distribution but after 48 hrs, the amount of substance P or CGRP immunoreactive nerve fibers were greatly reduced compared with the normal uterus. It is not clear whether the decrease of substance P and CGRP immunoreactive fibers in the uterus was resulted from the depletion of the neuropeptides in the nerve fibers or the retraction of nerve fibers. CONCLUSIONS: These results suggest that the inflammation should cause the change of nerve fibers included in the nociception. This change may attribute the generation of inflammation and inflammatory hyperalgesia.
Key Words: Substance P, CGRP, inflammation, nerve fiber
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 143 View
  • 0 Download
Related articles in Obstet Gynecol Sci

Article category

Browse all articles >


Browse all articles >

Editorial Office
4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea
Tel: +82-2-3445-2382    Fax: +82-2-3445-2440    E-mail: journal@ogscience.org                

Copyright © 2021 by Korean Society of Obstetrics and Gynecology. All rights reserved.

Developed in M2PI

Close layer
prev next