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Korean Journal of Obstetrics & Gynecology 2001;44(6):1040-1050.
Published online June 1, 2001.
Effect of superovulation on the expression of Tissue Inhibitor of Metalloproteinases-3 and Matrix Metalloproteinases-9 in murine endometrium.
Seung Yup Ku, Young Min Choi, Yon Su Kim, Jin Yong Lee
1Department of Obstetrics and Gynecology, College of Medicine.
2Institute of Reproductive Medicine and Population, Medical Research Center.
3Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Korea.
The effects of superovulation on the expression of mRNA and protein of TIMP-3 and MMP-9 in murine endometrium were assessed. METHODS: Using murine pregnant uteri of gestation day (g.d.) 4, 5 and 6 after injection of PMSG 5 and 10 IU, the effects of superovulation were assessed and compared with those of natural pregnancy and pseudopregnancy groups using quantitative competitive RT-PCR and immunohistochemical staining. RESULTS: Expression of TIMP-3 mRNA and protein showed an increase in PMSG groups and pseudopregnancy group, while there was no difference in MMP-9 expression between natural pregnancy and PMSG, pseudopregnancy groups on g.d. 4 through g.d. 6. CONCLUSIONS: This study suggests that ovarian hyperstimulation by gonadotropin, which produces many oocytes and embryos, may have a detrimental effect on embryonic implantation and its relevant endometrial remodeling process by increase in expression of TIMP-3 in murine endometrium.
Key Words: Superovulation, TIMP-3, MMP-9, Endometrium, Mouse

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