| Histologic Diagnosis of Cervcial Precursor Lesion: Applying the Bethesda System and HPV 16, 18 Correlates. |
|
Jong Lee, Mi Sook Kim, Chi Dong Han, Jeong Ja Park, Jae Bok Park, Tae Sung Lee |
1Department of Obstetrics and Gnecology, College of Medicine, Catholic University of Daegu.
2Department of Pathology, College of Medicine, Catholic University of Daegu. |
|
|
| Abstract |
|
OBJECT: To support the application of the Bethesda classification to the histologic diagnosis of cervical squamous lesions. METHODS: We evaluated the cervical biopsies and human papilloma virus (HPV) DNA status of 100 clinic patients. The 100 biopsy specimens were analyzed using criteria of the Bethesda system for low-grade squamous intraepithelial lesion(LSIL) and high-grade squamous intraepithelial lesions(HSIL) in association with analysis of HPV DNA virus type by PCR. RESULTS: By PCR amplified from paraffin embedded tissues, the 40 of 90 cases of classified as HSIL were HPV 16 or 18 positive and 1/10 cases of classified as LSIL was HPV 16 positive. CONCLUSION: This study supports the usefullness of certain histologic criteria of the Bethesda system for distinguishing squamous intraepithelial lesions into two grades. |
| Key Words:
Cervix, Human papillomavirus, PCR, The Bethesda System |
|
Full text via DOI
Download Citation
