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Korean Journal of Obstetrics & Gynecology 2001;44(8):1450-1454.
Published online August 1, 2001.
The Bone Response to Hormone Replacement Therapy according to Basal Bone Mineral Density in Postmenopausal Women.
Jung Gu Kim, Kwang Rai Kim, Byung Chul Gee, Seok Hyun Kim, Young Min Choi, Shin Yong Moon, Jin Yong Lee
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul 110-744, Korea.
To investigate the incidence of non-responder to hormone replacement therapy (HRT) and to evaluate the bone response to HRT according to basal bone mineral density(BMD) in postmenopausal women. METHODS: A total of 211 postmenopausal women received either continuous combined estrogen-progestogen replacement (n=112) or estrogen replacement (n=99) for 1 years. BMD at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry (DEXA) before and 1 year after HRT. RESULTS: The incidence of non-responder (women with > 3% bone loss per year) to HRT was 9.2% in the lumbar spine, and 23.8% in femoral neck. Estrogen replacement group had a higher incidence of non-responder than combined replacement group. Non-responder group had a higher basal BMD at the lumbar spine than responder group, and showed bone loss rate of 7.6% per year. After 1 year of HRT, postmenopausal women with osteoporosis showed a higher rate of increase in BMD at the lumbar sine and femoral neck than women with normal BMD or osteopenia. CONCLUSION: The non-responders to HRT have a higher basal lumbar BMD, compared with responders. The higher basal BMD at the lumbar spine is, the less bone conservation effect of HRT is.
Key Words: Hormone replacement therapy, osteoporosis, bone mineral density, Non-responder

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