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Korean Journal of Obstetrics & Gynecology 2001;44(9):1617-1620.
Published online September 1, 2001.
TNF-alpha concentration of plasma and peritoneal fluid in women with endometriosis: Dose TNF-alpha influence the pathogenesis of endometriosis.
Ho Sung Kim, Soo Mi Lee, Hee Gung Shin, Hye Kyoung Mun, Tae Il Cho, Jeong Bae Kang, Young Kyeong Lee
1Department of Obstetrics and Gynecology, Seoul Sung Ae General Hospital.
2Department of Obstetrics and Gynecology, Hallym University, College of Medicine, Seoul, Korea.
3Department of Clinical Pathology, Hallym University, College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE
Our purpose of study was to investigate whether in vivo levels of tumor necrosis factor-alpha in plasma and peritoneal fluid (PF) differ in women with and without endometriosis.Design : Prospective and case-control study. METHODS: Fifty-seven women with laparotomy or laparoscopic findings of minimal to severe endometriosis, and forty-two women with no visual evidence of pelvic endometriosis and with benign gynecologic disease. Tumor necrosis factor-alpha levels in plasma and PF were determined using commercial ELISA. Tumor necrosis factor-alpha concentrations were compared among women with and without endometriosis, and then also were compared according to the revised American Fertility Society classification. RESULTS: Tumor necrosis factor-alpha concentrations were not significantly increased in the plasma and PF of women with endometriosis than in matched normal controls. Tumor necrosis factor-alpha concentrations in endometriosis stage III and IV were sightly increased, which were not increased statistically significant. CONCLUSIONS: Plasma and PF tumor necrosis factor-alpha levels were not different between women with and without endometriosis. Our RESULTS: do not rule out the hypothesis that tumor necrosis factor-alpha may be involved in the pathogenesis of some features of endometriosis.
Key Words: Endometriosis, Tumor necrosis factor-alpha
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