| Thermolabile Methylenetetrahydrofolate Reductase Gene Variants in Korean Women with Severe Preeclampsia. |
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Ill Woon Ji, Eun Hwan Jeong, Hak Soon Kim, Yong Beom Kim, Jae Sook Rho, Seung Hwa Hong, Jeong Kyu Kim, Myeong Chan Cho |
1Department of Obstetrics and Gynecology, Chungbuk National University College of Medicine, Cheungju, Korea.
2Department of Internal Medicine, Chungbuk National University College of Medicine, Cardiology Division Cheungju, Korea. |
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| Abstract |
OBJECTIVE
This study was performed to evaluate C to T substitution at nucleotide 677 of meth-ylenetetrahydrofolate reductase gene in Korean women, which is genetically homogeneous, with preeclamptic or normotensive pregnancies. METHODS: Methylenetetrahydrofolate reductase genotypes were determined in 63 Korean women with severe preeclamptic pregnancies and 60 controls with normotensive pregnancies, using polymerase chain reaction and restriction enzyme analysis. RESULTS: The methylentetrahydrofolate reductase genotype and allele frequencies in preeclamptic and control women did not differ significantly. The frequency of the T677 allele was 38.1% in the preeclamptic group and 41.7% in the control group, and TT homozygosity was found in 12 preeclamptic women (19.0%) and 10 controls (16.7%). CONCLUSION: It seems like that there is no evidence of association of preeclampsia with meth-ylenetetrahydrofolate reductase gene polymorphism, at least in the Korean population. |
| Key Words:
Preeclampsia, Methylenetetrahydrofolate reductase, Polymorphism |
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