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Korean Journal of Obstetrics & Gynecology 2001;44(11):2104-2108.
Published online November 1, 2001.
Thermolabile Methylenetetrahydrofolate Reductase Gene Variants in Korean Women with Severe Preeclampsia.
Ill Woon Ji, Eun Hwan Jeong, Hak Soon Kim, Yong Beom Kim, Jae Sook Rho, Seung Hwa Hong, Jeong Kyu Kim, Myeong Chan Cho
1Department of Obstetrics and Gynecology, Chungbuk National University College of Medicine, Cheungju, Korea.
2Department of Internal Medicine, Chungbuk National University College of Medicine, Cardiology Division Cheungju, Korea.
Abstract
OBJECTIVE
This study was performed to evaluate C to T substitution at nucleotide 677 of meth-ylenetetrahydrofolate reductase gene in Korean women, which is genetically homogeneous, with preeclamptic or normotensive pregnancies. METHODS: Methylenetetrahydrofolate reductase genotypes were determined in 63 Korean women with severe preeclamptic pregnancies and 60 controls with normotensive pregnancies, using polymerase chain reaction and restriction enzyme analysis. RESULTS: The methylentetrahydrofolate reductase genotype and allele frequencies in preeclamptic and control women did not differ significantly. The frequency of the T677 allele was 38.1% in the preeclamptic group and 41.7% in the control group, and TT homozygosity was found in 12 preeclamptic women (19.0%) and 10 controls (16.7%). CONCLUSION: It seems like that there is no evidence of association of preeclampsia with meth-ylenetetrahydrofolate reductase gene polymorphism, at least in the Korean population.
Key Words: Preeclampsia, Methylenetetrahydrofolate reductase, Polymorphism


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