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Korean Journal of Obstetrics & Gynecology 2001;44(11):2109-2116.
Published online November 1, 2001.
Effect of postmenopausal hormone replecement therapy on leptin level and body composition.
Hyun Hee Jo, Young Oak Lew, In Cheul Jung, Dong Jin Kwon, Jang Heub Kim, Eun Jung Kim, Dae Hun Kim, Jin Hong Kim
Department of Obstetrics and Gynecology, Collage of Medicine, Catholic university, Seoul, Korea.
To compare the women who use postmenopausal hormone replacement therapy to never user for the serum leptin level and degree of obesity, then evaluate the precausing factor of postmenopausal obesity. METHOD: We checked the serum leptin level, blood chemistry and body composition in three groups, two groups are postmenopause groups which is HRT user (n=125) and HRT never user (n=194), and the other is premenopause groups(n=82). We used SPSS and Excel for analyzed the difference between the groups. RESULT: BMR is decreased after menopause, body fat ratio, abdominal fat ratio, BMI, leptin, sugar, and cholesterol level are increased after menopause. There is no difference between the postmenopausal HRT group and non-HRT group in body fat composition, abdominal fat ratio, BMI,BMR,AMC and leptin levels. Serum sugar level shows positive correlation with the leptin level in pre and postmenopausal women after exclude the effect of body fat ratio. Serum estradiol and leptin level shows positive correlation.(correlation coefficient 0.68 in postmenopausal non-HRT group and 0.735 in postmenopausal HRT group). CONCLUSION: Serum estradiol and sugar level have some correlation with leptin level and leptin resistance in postmenopausal women, and decreased estradiol level caused obesity through increased leptin resistance.
Key Words: Postmenopausal, HRT, Obesity, Leptin level

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