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Korean Journal of Obstetrics & Gynecology 2002;45(4):659-665.
Published online April 1, 2002.
The clinical significance of Interleukin-6 mRNA expression in cervical intraepithelial neoplasia and cervical cancer.
Hye Sung Moon, Eun Ah Choi, Hye Won Chung
Department of Obstetrics & Gynecology, College of Medicine, and Medical Research Center, Korea.
Abstract
OBJECTIVES
Interleukin-6 is a pleiotrophic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied IL-6 mRNA expression in cervical cancer, CIN and normal cervix. And we questioned whether its expression is related to cervical carcinogenesis and other prognostic factors. METHODS: The normal cervical and cervical cancer tissues were taken from healthy women (n=16), and the patients with CIN (n=36) and cervical cancer (n=36). The IL-6 mRNA expression was examined by quantitative competitive PCR after polymerase chain reaction amplification of reverse transcriptase copies of RNA transcripts (RT-PCR). RESULTS: There was no statistically different among cervical cancer, CIN and normal cervix (p>0.05). The IL-6 mRNA expression was not different according to the grades of CIN. Its expression was not correlated with the stage of cervical cancer, size of tumor, and histopathologic type (p>0.05). CONCLUSION: These results suggested that IL-6 mRNA expression might not be associated with the cervical carcinogenesis and prognosis of cervical cancer.
Key Words: IL-6, Cervical cancer, CIN, Carcinogenesis


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