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Korean Journal of Obstetrics & Gynecology 2002;45(4):714-717.
Published online April 1, 2002.
A Case of Kallmann Syndrome Conceived by Administration of Gonadotropin.
Yoon Sung Nam, Nam Keun Kim, Chang Jin Jeong, Sun Hee Cha, Kwang Yul Cha
1Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
2Department of Genetics, College of Medicine, Pocheon CHA University, Pocheon, Korea.
Abstract
Pulsatile secretion of GnRH from the hypothalamus is a prerequisite for both the initiation and maintenance of the reproductive axis in humans. Failure of this episodic GnRH secretion results in the clinical syndrome of hypogonadotropic hypogonadism. Deficient GnRH secretion may occur in isolation (idiopathic hypogonadotropic hypogonadism: IHH), in association with anosmia (Kallmann syndrome), or as a result of a variety of structural and functional lesions of the hypothalamic pituitary axis. The familial occurrence of hypogonadotropic hypogonadism associated with anosmia, color blindness, synkinesia, and mental defect is the classic Kallmann syndrome. Affected individuals respond readily to pulsatile administration of exogenous GnRH, and clearly this is the most physiologic approach to ovulation induction. For women not seeking pregnancy, replacement therapy with exogenous estrogen and progestin is indicated. We have experienced a case of Kallmann syndrome which was conceived by administration of gonadotropin. So we report this case with a brief review of literatures.
Key Words: Kallmann syndrome, Gonadotropin, Pregnancy


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