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Korean Journal of Obstetrics & Gynecology 2002;45(7):1209-1213.
Published online July 1, 2002.
Two Cases Reports of Prevention of Hypoglycemia with Administration of Insulin lispro on Diabetes in Pregnancy.
Un Ho Park, Jung Eun Lee, Sun Hwan Koh, Soo Bin Im, Jeong Rye Lee, Ji Young Lee, Sung Ook Hwang, Moon Whan Im, Woo Young Lee
Department of Obstetrics and Gynecology, College of medicine, Inha University, Inha Hospital, Korea.
Insulin therapy is indicated in the treatment of gestational diabetic women and overt diabetic pregnant women for hyperglycemia after failure to respond to the diets and exercise regimens. The insulin is administered to mimic normal pancreatic function. The normal pancreas secretes 50% of the total daily insulin as mealtime boluses. This delivery may be mimicked by four-injection-per-day of combination of NPH and regular insulin (RI). Hypoglycemia is a well-recognized complication of intensive insulin therapy in patients with Type II diabetes. Recently, it has been reported that insulin-lispro, an analogue of regular human insulin with a peak insulin action achieved with a 1 hour after injection improves postprandial glucose concentration in non-pregnant diabetic patients. Treatment of gestational or diabetic pregnant women with NPH and insulin-lispro has significantly lower postprandial glucose levels without an increase in hypoglycemic events. Here, we report 2 cases of hyperglycemic control with four times daily administration of NPH & insulin-lispro on diabetes in pregnancy, with brief reviews.
Key Words: Diabetes mellitus, Insulin, A four-injection-per-day, Hypoglycemia, Insulin-lispro

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