Extraovarian endodermal sinus tumor arising from myometrium: A case report.

Kwon, Hae Eun; Kim, Mi Kyung; Kim, Sook Hee; Na, Sung Hun; Kwon, Yong Soon; Hwang, Jong Yun; Nam, Joo Hyun

Case Report

Korean Journal of Obstetrics & Gynecology 2002;45(7):1241-1245.
Published online July 1, 2002.

Extraovarian endodermal sinus tumor arising from myometrium: A case report.

Hae Eun Kwon, Mi Kyung Kim, Sook Hee Kim, Sung Hun Na, Yong Soon Kwon, Jong Yun Hwang, Joo Hyun Nam

Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.

Abstract

Endodermal sinus tumor (EST) is not so common germ cell neoplasm which arises most commonly in the ovary. The extraovarian sites such as the upper female genital tract are rare sites of origin. The 26-year-old female patient was found to have hemoperitoneum. Emergency laparotomy at local clinic, revealed a 8 cm sized mass, which arose from the anterior myometrium. Because both of the ovaries appeared to be normal, the tumor was thought to be originated from the myometrium. The excision of tumor mass was performed and the permanent biopsy confirmed the mass as EST histologically. The patient was transferred to AMC and staging operation including hystrectomy, left salpingooophorectomy, omentectomy, retroperitoneal lymph node (LN) and paraaortic LN dissection, appendectomy was performed and no metastasis was found. She received 6 cycles of combination chemotherapy (bleomycin, etoposide, and cisplatinum). Her serum alpha-fetoprotein (AFP) level dropped to normal from the initial level of 19,300 ng/ml. In the author's knowledge, the myometrium has not been reported as a site of EST origin. So we report this case with brief review of the literatures.

Key Words: Endodermal sinus tumor, Myometrium