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Korean Journal of Obstetrics & Gynecology 2002;45(8):1330-1335.
Published online August 1, 2002.
Comparative Study on Treatment of Postmenopausal Symptoms with Black Cohosh Root Extract and Hormone Replacement Therapy.
Byoung Ick Lee, Seung Kwon Koh, Seong Ook Hwang, Jee Hyun Park, Chong Wha Kim
1Department of Obstetrics and Gynecology, Inha University Hospital, College of Medicine Inha University, Incheon, Korea.
2Department of Obstetrics and Gynecology, Samsung Medical Center, College of Medicine, Sunkyunkwan University, Seoul, Korea.
Abstract
OBJECTIVE
The fears and side effects of a prolonged hormone replacement therapy on the postmenopausal symptoms reinforce a growing interest about alternatives. The present study was performed to investigate whether black cohosh root extract (BCRE) can be used or not as an alternative to hormone replacement therapy (HRT) in order to relieve postmenopausal symptoms. MATERIAL & METHODS: Randomized, double-blind prospective clinical trial examined the effects of BCRE and HRT on Kupperman index, biochemical bone markers, lipid profiles, and side effects in 74 women with postmenopausal symptoms. Treatments included placebo (Festal(R)) (n=12), BCRE (Feramin(R)) (n=32) and HRT (Premarin(R)) (n=30) for 3 months. Kupperman index, biochemical bone markers (osteocalcin and deoxypyridinoline), and lipid profiles (total cholesterol, triglyceride and HDL-cholesterol) were measured at 0, 1 and 3 months. Side effects were checked at 3 months. RESULTS: BCRE was significantly effective in lowering of Kupperman index as much as HRT at two control times (1 month: p<0.05, 3 months: p<0.001). It also showed slightly favorable effects on biochemical bone markers and lipid profiles but not statistically significant. Fewer side effects were seen in BCRE than HRT. CONCLUSION: BCRE appears to be a safe and effective alternative to HRT for early postmenopausal symptoms and may be especially useful in women with intolerances or contraindications to traditional HRT.
Key Words: Black cohosh root extract (BCRE), hormone replacement therapy (HRT), Kupperman index, Biochemical bone markers, Lipid profiles, Side effects


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