De novo Fetal Chromosomal Abnormalities after Assisted Reproductive Technology.

Ahn, Ki Heon; Lee, Kook One; Joo, Jong Kil; Shin, Byung Sup; Choi, Ook Hwan

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Korean Journal of Obstetrics & Gynecology 2002;45(9):1606-1610.
Published online September 1, 2002.

De novo Fetal Chromosomal Abnormalities after Assisted Reproductive Technology.

Ki Heon Ahn, Kook One Lee, Jong Kil Joo, Byung Sup Shin, Ook Hwan Choi

Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Pusan, Korea.

Abstract

We experienced two cases of de novo fetal chromosomal abnormalities after assisted reproductive technology (ART): One case was reciprocal translocation 46,XX,t(6;14)(p21.3;q12) after intracytoplasmic sperm injection and embryo transfer (ICSI-ET) and the other case was 46,X,iso(Xq) after in vitro fertilizaton and embryo transfer (IVF-ET), both were diagnosed prenatally by amniocentesis and postnatally cord blood culture. We report these cases with a brief review of literatures.

Key Words: ART (IVF, ICSI), De novo chromosomal abnormality, 46,XX,t(6, 14)(p21.3, q12), 46,X,iso(Xq)

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