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Korean Journal of Obstetrics & Gynecology 2002;45(10):1746-1751.
Published online October 1, 2002.
Preoperative Pap Smears in Endometrial Carcinoma: The Clinicopathologic Relevance.
Seok Ju Seong, Tae Jin Kim, Kyung Taek Lim, Hwan Wook Chung, Ki Heon Lee, In Sou Park, Jae Uk Shim, Chong Taik Park, Hye Sun Kim, Hy Sook Kim
1Department of Obstetrics and Gynecology, Samsung Cheil Hospital and Women's Healthcare Center Sungkyunkwan University School of Medicine, Seoul, Korea.
2Department of Pathology, Samsung Cheil Hospital and Women's Healthcare Center Sungkyunkwan University School of Medicine, Seoul, Korea.
The aim of this study was to evaluate the correlation between preoperative Pap smears and known poor prognostic factors in patients with endometrial carcinoma. METHODS: Between January 1989 and June 2000, preoperative evaluation of Pap smears were done in 163 patients with endometrial carcinoma who underwent total abdominal hysterectomy with bilateral salpingo- oophorectomy, peritoneal cytology, and pelvic and/or para-aortic lymphadenectomy. All Pap smears and histologic sections were reviewed. Pathologic parameters of hysterectomy specimens were evaluated and correlated with the findings of Pap smears. Chi-square test was used for statistical analysis. p-values<0.05 were considered significant. RESULTS: The mean age of patients was 49 years with range between 24 and 75 years old. 72 patients (44.2%) had normal, 38 patients (23.3%) had atypical glandular cells of undetermined significance (AGUS), and 53 (32.5%) had adenocarcinoma on preoperative Pap smears. Statistically significant associations were found between Pap smears and age (p=.014), histologic grade (p=.000), cervical involvement (p=.015), depth of myometrial invasion (p=.000), lymph-vascular space invasion (p=.000), and surgical stage (p=.049). Patients with malignant cytology were more likely to have older age, poorly differentiated malignancies, deeper myometrial invasion, cervical metastases, lymphvascular invasion and higher surgical stage. However, histologic subtypes (p=.328), peritoneal cytology (p=.067), adnexal involvement (p=.602) and pelvic and/or para-aortic lymph node metastases (p=.266 and p=.220) were not statistically significant. CONCLUSION: This study revealed that preoperative abnormal Pap smears in patients with endometrial carcinoma were significantly associated with age, histologic grade, cervical involvement, depth of myometrial invasion, lymphvascular space invasion and surgical stage. Therefore, Pap smears could be an important part of the preoperative evaluation in patients with endometrial carcinoma.
Key Words: Pap smear, Endometrial carcinoma, AGUS, Prognostic factors

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