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Korean Journal of Obstetrics & Gynecology 2002;45(10):1794-1799.
Published online October 1, 2002.
Response for radiation therapy and p53, bcl-2 and bax protein expressions in uterine cervical carcinoma.
Eui Don Lee, Kwang Beom Lee, Won Ik Suk, Jun Ryeoul Choi, Jong Min Lee, Chan Yong Park, Seung Yeon Ha, Lee Kyu Chan
1Department of Obstetrics and Gynecology, Gachon Medical School, Inchon, Korea.
2Department of Radication Oncology, Gachon Medical School, Inchon, Korea.
3Department of Pathology, Gachon Medical School, Inchon, Korea.
Abstract
OBJECTIVE
To evaluate the relationship between p53, bcl-2 and bax protein expressions and clinical response to radiation therapy in patients with cervical squamous cell carcinoma and possibility of using them as an useful marker for sensitivity of radiation therapy. METHODS: This study included 30 patients with locally advanced cervical squamous cell carcinoma (stage IIb and III). The specimens were obtained from cervical squamous cell carcinoma before radiation therapy by colposcopic directed biopsy and processed for immunohistochemical staining against p53, bcl-2 and bax. RESULTS: 1. P53 was more expressed in nonresponders than responders to radiation therapy, but it was not statistically significantly different (p=0.43). 2. Bcl-2 was significantly more expressed in nonresponders than responders to radiation therapy (p=0.001). 3. Bax was significantly more expressed in responders than nonresponders to radiation therapy (p=0.04). CONCLUSION: Expression of bcl-2 and bax are correlated with the clinical response to radiation therapy and would be considered as an useful marker for sensitivity of radiation therapy. However, it is necessary to further evaluate p53.
Key Words: cervical carcinoma, radiation therapy, p53, bcl-2, bax


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