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Korean Journal of Obstetrics & Gynecology 2002;45(12):2124-2129.
Published online December 1, 2002.
Expression of c-erbB-2 Oncoprotein and DNA Topoisomerase II-alpha in Premalignant Lesions and Invasive Squamous Cell Carcinomas of the Uterine Cervix.
Seung Ho Shin, Hong Mo Koo, Jin Seak Kim, Hye Kyoung Mun, Jae Deok Lee, Sang Yong Kim, Jae Hee Han, Tae Il Cho, Tae Jin Lee
1Department of Obstetrics and Gynecology, Kwang Myung Sung Ae Hospital, Seoul, Korea.
2Department of Obstetrics and Gynecology, Sung Ae General Hospital, Seoul, Korea.
3Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Korea.
The relationship was studied between expression of c-erbB-2 oncoprotein and topoisomerase II-alpha as proliferating marker in precancerous lesions and invasive squamous carcinomas of the uterine cervix. METHODS: Total 81 formalin-fixed, paraffin-embedded sections of low-grade intrasquamous lesion (22 cases), high-grade intraepithelial lesions (42 cases) and invasive squamous cell carcinomas (17 cases) in the uterine cervix were stained by immunohistochemistry for expression of the c-erbB-2 oncoprotein and topoisomerase II-alpha. RESULTS: The expression of c-erbB-2 oncoprotein and staining index (mean+/-S.D) of topoisomerase II-alpha were statistically significant between precancerous lesions and invasive carcinoma. The expression of c-erbB-2 oncoprotein has correlation with staining index (mean+/-S.D) of topoisomerase II-alpha. CONCLUSION: There results suggest that the expression of c-erbB-2 protein has relationship with progression of squamous lesions and topoisomerase II-alpha is an useful proliferating marker in the uterine cervix. And, the expression of c-erbB-2 protein has correlation with expression of topoisomerase II-alpha.
Key Words: c-erbB-2, topoisomerase II-alpha, uterine cervix, precancerous lesion, invasive squamous cell carcinoma

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