Nonimmune hydrops fetalis: clinical characteristics and prognostic factors of neonatal survival.

Lee, Joong Yeup; Sohn, Yoo Kyung; Shim, Soon Sup; Im, June Hee; Shim, Jae Yoon; Park, Joong Shin; Jun, Jong Kwan; Yoon, Bo Hyun; Syn, Hee Chul

Original Article

Korean Journal of Obstetrics & Gynecology 2002;45(12):2196-2202.
Published online December 1, 2002.

Nonimmune hydrops fetalis: clinical characteristics and prognostic factors of neonatal survival.

Joong Yeup Lee, Yoo Kyung Sohn, Soon Sup Shim, June Hee Im, Jae Yoon Shim, Joong Shin Park, Jong Kwan Jun, Bo Hyun Yoon, Hee Chul Syn

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

OBJECTIVE
We undertook this study to find out clinical characteristics and prognostic factors of neonatal survival in nonimmune hydrops fetalis (NIHF). METHODS: From Oct. 1988 to Feb. 2001, 54 cases of nonimmune hydrops fetalis diagnosed at Seoul National University Hospital (SNUH) were included in our study. The incidence and perinatal mortality were investigated. The diagnostic work-up for associated conditions (or etiology) included detailed ultrasonography, karyotyping, fetal echocardiography, infection work-up (TORCH, parvovirus), and autopsy (if fetus was dead). Among 54 cases, 20 cases of liveborns were divided into two groups. Group I survived beyond neonatal period (survived>28 days) and group II did not (expired3 (OR=21, CI 1.77, 248.1; p<0.05), and 5-min AS>3 (p<0.01). CONCLUSION: Over 3 of 1-min and 5-min AS were meaningful factors for neonatal survival in NIHF.

Key Words: Nonimmune hydrops fetalis, Prognostic factor, Neonatal outcome, Fetal outcome, Intrauterine treatment