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Korean Journal of Obstetrics & Gynecology 2003;46(4):842-846.
Published online April 1, 2003.
A Case of Glassy Cell Carcinoma of the Uterine Cervix with Photodynamic Therapy prior to Radical Surgery.
Yong Wook Kim, Cheol Hoon Park, Duck Yeong Ro, Jeong Im Sin, Su Mi Bae, Joon Mo Lee, Sung Eun Namkoong, Victor Sokolov, Woong Shick Ahn
1Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
2Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea.
3P.A. Hertzen Moscow Research Oncologycal Institute, 2d Botkinskij pr., Moscow, Russia.
Abstract
It has been known that glassy cell carcinoma (GCC) of uterine cervix is rare and rapidly progressive, and has a poor prognosis. Here we describe a case of GCC in which photodynamic therapy (PDT) was performed prior to radical hysterectomy. The patient, a 42 year-old woman at the stage of FIGO Ib2 underwent interstitial PDT (Photogem, 2 mg/kg; light, p=100 mV, W=100 J/cm2, 15 min/each 4 direction). The cervical lesion displayed inflammation and necrosis at 48 h following PDT. At 2 weeks post PDT, inflammatory reaction was disappeared and the tumor volume was decreased. No side effects of PDT were also observed. Subsequently, the patient underwent radical hysterectomy and pelvic lymph node resection. This case suggests that PDT prior to radical surgery might be an effective way to reduce tumor size without any side effects. More cycles of PDT might be beneficial for treating GCC of the uterine cervix.
Key Words: Glassy cell carcinoma, Uterine cervix, Photodynamic therapy, Chemotherapy


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