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Korean Journal of Obstetrics & Gynecology 2003;46(7):1300-1305.
Published online July 1, 2003.
The Association of GSTM1 and GSTT1 Null Polymorphisms with Endometriosis in a Korean Population.
Tai June Kim, Seok Hyun Kim, Young Min Choi, Jong Kwan Jun, Sung Hyo Park, In Ae Park, Seung Yup Ku, Chang Suk Suh, Jung Gu Kim, Shin Yong Moon, Yong Tack Lim
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
2Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Korea.
3Department of Pathology, Seoul National University College of Medicine, Korea.
4Department of Obstetrics and Gynecology, Catholic University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE
To explore the association of the phase II glutathione S-transferase mu (GSTM1), theta (GSTT1) gene null polymorphisms with endometriosis in a Korean population. METHODS: One hundred forty eight women with surgically diagnosed endometriosis of stage I-IV were recruited. And 130 patients with no evidence of endometriosis by laparoscopy or laparotomy served as controls. Genomic DNA was extracted from peripheral blood and analyzed for GSTM1, GSTT1 null polymorphisms. RESULTS: GSTM1 null genotype (GSTM1 0/0) was found more frequently in patients with endometriosis than in controls (61.5% in endometriosis vs. 49.2% in control, p=0.040). And the association was found only in moderate to severe endometriosis (stage III IV) (63.7% vs. 49.2%, p=0.027: odds ratio: 1.812), not in minimal or mild endometriosis (p=0.395). There was no significant difference between endometriosis patients and controls in the frequency of the GSTT1 null genotype (51.4% vs. 54.6%, p>0.1). CONCLUSION: These results suggest that GSTM1 null genotype is associated with the risk of endometriosis but GSTT1 null genotype is not in the Korean population.
Key Words: Glutathione s-transferase, Polymorphism, Endometriosis


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