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Korean Journal of Obstetrics & Gynecology 2003;46(8):1531-1536.
Published online August 1, 2003.
Estrogen Receptor Gene PvuII and XbaI Polymorphism in Patients with Endometriosis.
Young Min Choi, Seung Yup Ku, Kyu Ri Hwang, Yong Tack Lim, Sung Hyo Park, Jong Kwan Jun, Noh Hyun Park, In Ae Park, Chang Suk Suh, Seok Hyun Kim, Jung Gu Kim, Shin Yong Moon
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
2Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Korea.
3Department of Pathology, Seoul National University College of Medicine, Korea.
4Department of Obstetrics and Gynecology, Catholic University College of Medicine, Korea.
Abstract
OBJECTIVE
To explore the association of the estrogen receptor PvuII and XbaI polymorphism with endometriosis. METHODS: One hundred sixty women with surgically or histologically diagnosed endometriosis of stages I-IV, and 142 patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. Frequency and distribution of PvuII and XbaI polymorphisms for estrogen receptor gene were evaluated. RESULTS: There was no statistically significant difference in the allele distribution of PvuII polymorphism between the patients and the controls (pp of 35%, pP of 51%, PP of 14% vs. 42%, 44%, 15%, p>0.1); or in the frequency of the positive PvuII allele (0.61 vs. 0.63, p>0.1). And no significant difference was also observed in the allele distribution of XbaI polymorphism between the patients and the controls (xx of 66%, xX of 29%, XX of 5% vs. 68%, 30%, 1%, p>0.1); or in the frequency of the positive XbaI allele (0.80 vs. 0.83, p>0.1). CONCLUSION: These results suggest that the PvuII or XbaI polymorphism of the estrogen receptor gene is not associated with the risk for endometriosis in the Korean population.
Key Words: Endometriosis, Estrogen receptor gene, Polymorphism, PvuII, XbaI


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