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Korean Journal of Obstetrics & Gynecology 2003;46(9):1790-1796.
Published online September 1, 2003.
A Case of Malignant Mixed Mullerian Tumor of Uterus after Tamoxifen Therapy for Breast Cancer.
Eon Ah Kim, Hae Young Choi, Moo Hee Kim, Sa Ra Lee, Han Moie Park, Hye Sung Moon, Seung Cheol Kim, Byung In Moon, Yoon Sup Han
1Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea.
2Department of General Surgery, College of Medicine, Ewha Womans University, Seoul, Korea.
3Department of Pathology, College of Medicine, Ewha Womans University, Seoul, Korea.
Tamoxifen is widely used for the treatment of breast cancer and currently proposed for preventive strategies. However. there is evidence that tamoxifen may affect other hormone sensitive organs, such as uterus and ovary. It has been documented that tamoxifen treatment is associated with development of endometrial polyp, endometrial hyperplasia, ovarian and endometrial cancer. Uterine malignant mixed mullerian tumor is a neoplasm which apparently arises from undifferentiated mullerian stroma and is composed of a mixture of malignant epithelial and stromal component. We report a case of malignant mixed mullerian tumor of uterus which was developed in a patient treated with tamoxifen for 5 years following a modified radical mastectomy due to breast cancer.
Key Words: Malignant mixed mullerian tumor, Uterus, Tamoxifen, Breast cancer

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