A Case of Thrombotic Thrombocytopenic Purpura in Pregnancy.

Kim, Jong Min; Lee, Hae Hyeog; Kim, Tae Hee; Kim, Hyeong Mun; Yeo, So Jin; Nam, Kye Hyun; Shim, Yil Ku; Lee, Kwon Hae

Case Report

Korean Journal of Obstetrics & Gynecology 2003;46(10):2079-2082.
Published online October 1, 2003.

A Case of Thrombotic Thrombocytopenic Purpura in Pregnancy.

Jong Min Kim, Hae Hyeog Lee, Tae Hee Kim, Hyeong Mun Kim, So Jin Yeo, Kye Hyun Nam, Yil Ku Shim, Kwon Hae Lee

Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Bucheon, Korea.

Abstract

Thrombotic thrombocytopenic purpura (TTP) is quiet rare, with 1 of 25,000 delivery and complicating pregnancy is associated with high maternal mortality and long-term morbidity. Unfortunately the clinical appearance of thrombotic thrombocytopenic purpura is similar with the syndrome of hemolysis, elevated liver enzyme, and low platelet (HELLP), but the treatment of this differs from that of the HELLP syndrome or acute fatty liver of pregnancy, therefore accurate diagnosis is essential for optimal therapy. The survival of this disorder has been improved due to aggressive treatment with plasma transfusion or plasmapheresis. We have experienced a case of thrombotic thrombocytopenic purpura confused with HELLP syndrome of preeclampsia, so we report it with a brief review of literature.

Key Words: Thrombotic thrombocytopenic purpura, HELLP syndrome, Plasmapheresis