N-acetyl Transferase 2 Gene Polymorphisms in Patients with Endometriosis.

Choi, Young Min; Yoon, Ji Sung; Ku, Seung Yup; Lee, Kyu Sup; Park, Sung Hyo; Chang, Eun Ran; Park, Noh Hyun; Park, In Ae; Jun, Jong Kwan; Suh, Chang Suk; Kim, Seok Hyun; Kim, Jung Gu; Moon, Shin Yong

Obstet Gynecol Sci > Volume 46(11); 2003 > Article

Original Article

Korean Journal of Obstetrics & Gynecology 2003;46(11):2113-2117.
Published online November 1, 2003.

N-acetyl Transferase 2 Gene Polymorphisms in Patients with Endometriosis.

Young Min Choi, Ji Sung Yoon, Seung Yup Ku, Kyu Sup Lee, Sung Hyo Park, Eun Ran Chang, Noh Hyun Park, In Ae Park, Jong Kwan Jun, Chang Suk Suh, Seok Hyun Kim, Jung Gu Kim, Shin Yong Moon

¹Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
²Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Korea.
³Medical Research Center, Seoul National University College of Medicine, Korea.
⁴Department of Pathology, Seoul National University College of Medicine, Korea.
⁵Department of Obstetrics and Gynecology, Busan University College of Medicine, Korea.

Abstract

OBJECTIVE
To explore the association of the N-acetyl transferase 2 (NAT 2) gene polymorphisms with endometriosis. METHODS: One hundred seventy-two women with surgically or histologically diagnosed endometriosis of stages I-IV, and 205 patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. Genotype distribution of NAT 2 polymorphisms and frequencies of slow and fast acetylators in affected women and controls were evaluated. RESULTS: There was no statistically significant difference in the genotype distribution of NAT 2 polymorphisms and frequencies of slow and fast acetylators between the patients with endometriosis and the controls. CONCLUSION: These results suggest that N-acetyl transferase 2 gene polymorphisms is not associated with the risk for endometriosis in the Korean population.

Key Words: Endometriosis, N-acetyl transferase 2, NAT 2 gene, Polymorphism