| Expression of TRAIL (Apo-2L)/TRAIL Receptor System Related to Apoptosis at the Human Extraembryonic Tissues and Gestational Trophoblastic Disease. |
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In Bai Chung, Dong Soo Cha, Jun Hyung Sohn, Seung Jin Choi, Kyoung Hee Han |
1Department of Obstetrics and Gynecology, Yonsei University, Wonju College of Medicine, Wonju, Kangwon-do, Korea.
2Department of Biochemistry, Yonsei University, Wonju College of Medicine, Wonju, Kangwon-do, Korea.
3Institute of Basic Science, Yonsei University, Wonju College of Medicine, Wonju, Kangwon-do, Korea. |
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| Abstract |
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Human uterus has been known as a immune privileged site for the product of conception. At the feto-maternal interface, Fas system is a underlying main mechanism of maternal immune acceptance. To date, the TRAIL (TNF-related apoptosis-inducing ligand) system is known to be another pivotal mechanism. OBJECTIVE: To clarify the protein expression of TRAIL ligand and receptors in the normal and pathologic (preeclampsia, hydatidiform mole) placenta, chorioamnion, decidua. METHODS: we investigated the expression of TRAIL system in the above-mentioned tissues by using Western Hybridization. RESULTS: All tissues expressed TRAIL ligand and only a DcR2 among TRAIL receptors (DR4, DR5, DcR1, DcR2). CONCLUSION: we demonstrated the expression of TRAIL ligand and DcR2 protein at the feto-maternal interface of the normal and pathologic pregnancies. Further study regarding the expression of other receptors and quantitative analysis between normal and pathologic pregnancies should be followed. |
| Key Words:
Apoptosis, Feto-maternal interface, TRAIL (Apo-2L)/TRAIL receptor system |
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