Clinical Analysis of 896 Cases of Midtrimester Amniocentesis.

Lee, Hyang Ah; Choi, Seong Jin; Chung, In Bai; Cha, Dong Soo; Han, Kyoung Hee; Kim, Hyo Eon; Yoon, Kap Jun

Original Article

Korean Journal of Obstetrics & Gynecology 2003;46(11):2203-2208.
Published online November 1, 2003.

Clinical Analysis of 896 Cases of Midtrimester Amniocentesis.

Hyang Ah Lee, Seong Jin Choi, In Bai Chung, Dong Soo Cha, Kyoung Hee Han, Hyo Eon Kim, Kap Jun Yoon

Department of Obstetrics and Gynecology, Clinicopathology, Yonsei University, Wonju College of Medicine, Wonju, Korea.

Abstract

OBJECTIVE
We report our experience with midtrimester amniocentesis. METHODS: This study was retrospectively reviewed 896 cases of midtrimester genetic amniocentesis from January 1997 to October 2003 in Yonsei university, Wonju Colleage of medicine. We analyzed the indications, distributions of gestational age, cytogenetic results, and the safety. RESULTS: The most common Indications for amniocentesis were abnormal maternal serum marker (52.7%) and advanced maternal age (36.6%). Most amniocentesis has been performed during second trimester from 16 to 20 weeks. The incidence of chromosomal abnormality was 3.9% (35 cases). There were 26 cases of numerical aberration, 6 cases of structural aberration and 3 cases of mosaicism. In chromosomal aberration, there was 9.0% (2/22) of chromosomal abnormalities in abnormal ultrasonographic finding group and 6.9% (2/29) in previous chromosomal anomaly. There were 3 cases of fetal loss (0.3%) after amniocentesis. CONCLUSION: Midtrimester amniocentesis is a useful and safe technique for the prenatal detection of genetic disorder.

Key Words: Amniocentesis, Chromosomal abnormality