A Case of Acute Myelogenous Leukemia During Pregnancy.

Kim, Hoon; Seong, Hyo Sook; Ju, Woong; Lee, Kyung Soo; Hong, Jun Seok; Shim, Soon Sup; Park, Joong Shin; Jun, Jong Kwan; Yoon, Bo Hyun; Syn, Hee Chul

Case Report

Korean Journal of Obstetrics & Gynecology 2004;47(2):372-376.
Published online February 1, 2004.

A Case of Acute Myelogenous Leukemia During Pregnancy.

Hoon Kim, Hyo Sook Seong, Woong Ju, Kyung Soo Lee, Jun Seok Hong, Soon Sup Shim, Joong Shin Park, Jong Kwan Jun, Bo Hyun Yoon, Hee Chul Syn

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

Acute leukemia is one of the most common malignant neoplasms of female. Fortunately, the incidence of leukemia during pregnancy has been estimated at only 1 per 100,000 pregnancies. Since the management of acute leukemia in pregnancy consists of the challenge of optimizing chances for prolonged remission and cure in the mother while minimizing the toxicity to the unborn fetus, so there are many therapeutic and ethical dilemmas. Causing thrombocytopenia and anemia, neutropenia, leukemia can be an obstacle to the adequate obstetric management. The management of this subset of pregnant patients requires a team approach including patient, family, obstetrician and hematologist-oncologist. We experienced a case of the pregnancy with acute myelogenous leukemia at 32 gestational weeks. With induction of labor, she was delivered of a 2,250 g, healthy male baby at 34 gestational weeks. After delivery of infant, she underwent combination chemotherapy. We present this case with review of related literatures.

Key Words: Acute leukemia, Pregnancy, Cancer