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Korean Journal of Obstetrics & Gynecology 2004;47(3):451-457.
Published online March 1, 2004.
Effect of Surgical Therapy on the Courses of Human Papillomavirus Infection in Cervical Intraepithelial Neoplasia.
Jin Lae Roh, Jae Wook Kim, Young Tae Kim, Sung Hoon Kim, Kun Hong Kim
1Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
2Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, Korea.
To investigate whether human papillomavirus (HPV) associated with cervical intraepithelial neoplasia was successfully eliminated after surgical therapy such as large loop excision of transformation zone (LLETZ) or type I extended hysterectomy. METHODS: Seventy four cervical intraepithelial neoplasia (CIN) patients with HPV infection who were admitted for LLETZ or type I extended hysterectomy were recruited into this prospective study. HPV infection was confirmed by HPV DNA genotyping using HPV DNA Chip (Biomedlab, Seoul, Korea) before and after surgical therapy. RESULTS: According to the assay used (HPV DNA Chip(R)) at the postoperative visit, 82.5% of treated patients were completely free from HPV infection. And there was no statistical difference between LLETZ and type I extended hysterectomy (p=0.452). However, there was persistent infection in 17.5% of treated patients after final surgical therapy. CONCLUSION: Although the HPV infection associated with CIN was effectively eliminated after LLETZ and type I extended hysterectomy, there was persistent infection in 17.5% of treated patients. Therefore, the careful followed-up examination of HPV infection should be taken in these patients.
Key Words: Human papillomavirus (HPV), Cervical intraepithelial neoplasia (CIN), HPV DNA genotyping, Surgical therapy

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