Effect of Surgical Therapy on the Courses of Human Papillomavirus Infection in Cervical Intraepithelial Neoplasia. |
Jin Lae Roh, Jae Wook Kim, Young Tae Kim, Sung Hoon Kim, Kun Hong Kim |
1Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. 2Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, Korea. |
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Abstract |
OBJECTIVE To investigate whether human papillomavirus (HPV) associated with cervical intraepithelial neoplasia was successfully eliminated after surgical therapy such as large loop excision of transformation zone (LLETZ) or type I extended hysterectomy. METHODS: Seventy four cervical intraepithelial neoplasia (CIN) patients with HPV infection who were admitted for LLETZ or type I extended hysterectomy were recruited into this prospective study. HPV infection was confirmed by HPV DNA genotyping using HPV DNA Chip (Biomedlab, Seoul, Korea) before and after surgical therapy. RESULTS: According to the assay used (HPV DNA Chip(R)) at the postoperative visit, 82.5% of treated patients were completely free from HPV infection. And there was no statistical difference between LLETZ and type I extended hysterectomy (p=0.452). However, there was persistent infection in 17.5% of treated patients after final surgical therapy. CONCLUSION: Although the HPV infection associated with CIN was effectively eliminated after LLETZ and type I extended hysterectomy, there was persistent infection in 17.5% of treated patients. Therefore, the careful followed-up examination of HPV infection should be taken in these patients. |
Key Words:
Human papillomavirus (HPV), Cervical intraepithelial neoplasia (CIN), HPV DNA genotyping, Surgical therapy |
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