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Korean Journal of Obstetrics & Gynecology 2004;47(3):531-536.
Published online March 1, 2004.
Expression pattern of Aromatase Cytochrome P450 in Adenomyosis.
Yun Jung Lee, Ji Young Kim, Young Se Park, Yong Min Kim, Jin Beum Jang, Dong Jae Cho, Jae Wook Kim, Woo Ick Yang
1Department of Obsterics and Gynecology, Pochon CHA University Medical College, Kangnam, Korea.
2Department of Pathology, Pochon CHA University Medical College, Kangnam, Korea.
3Department of Obsterics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE
To determine whether local estrogen production takes place in adenomyosis and in normal endometrium. METHODS: The study included 23 cases of adenomyosis and 17 cases of normal uterine endometrium obtained through hysterectomy or curettage at Kangnam Cha Hospital. The frozen tissue specimens were examined by immunohistochemistry using P450 arom. RESULTS: P450 arom was immunolocalized exclusively in the cytoplasm of glandular cells of adenomyotic tissue. However, no apparent staining was observed in stromal cells. Aromatase was expressed in the ectopic glands (82.6%), but also in the eutopic endometrium of patients with adenomyosis (23.5%). In the case of normal endometrium, P450arom was not detected. CONCLUSION: These results suggest that the aromatase activity is correlated to the pathophysiology of adenomyosis.
Key Words: Aromatase, Adenomyosis, Normal endometrium, Immunohistochemistry
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