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Korean Journal of Obstetrics & Gynecology 2004;47(4):702-707.
Published online April 1, 2004.
Increased Oxidative Stress Affects the Neonatal Birth Weight in Preeclamptic Patients.
Young Ju Kim, Hye Sook Park, Mi Hye Park, Woo Kyoung Kim, Eun Ae Park, Eun Hee Ha, Yun Chul Hong, Namsoo Chang, Myung Geol Pang
1Department of Obstetrics and Gynecology, Ewha Womans University, Seoul, Korea.
2Department of Preventive Medicine, Ewha Womans University, Seoul, Korea.
3Medical Research Center, Ewha Womans University, Seoul, Korea.
4Department of Food Science and Nutrition, Dankook University, Seoul, Korea.
5Department of Pediatrics, Ewha Womans University, Seoul, Korea.
6Department of Occupational and Environmental Medicine, Inha University College of Medicine, Incheon, Korea.
7Department of Food and Nutritional Science, Ewha Womans University, Seoul, Korea.
8Department of Animal Science and Technology, College of Industrial Sciences, Chung-Ang University, Gyungi-Do, Korea.
Abstract
OBJECTIVE
To assess the maternal circulating levels of homocysteine, the thiobarbituric acid reactive substances (TBARS) and the glutathione peroxidase (GPX) activities, and to determine whether or not these markers have any effect on the neonatal birth weight in preeclamptic patients. METHODS: A case control study of 74 normal pregnant women and 47 preeclamptic patients who were hospitalized for delivery and had singleton live births between 2000 and 2002 was conducted. The birth weight, gestational age, and maternal circulating level of homocysteine, the TBARS, the GPX activities, and the antioxidant capacity (GPX/TBARS) were measured. GPX genotyping was done with the maternal DNA samples. The results were analyzed with a Chi-square test, student T-test, and logistic regression analyses. RESULTS: The homocysteine and TBARS levels were significantly higher in the preeclamptic patients than in the pregnant controls (p=0.0098 for homocysteine, p<0.0001 for TBARS). The antioxidant capacity (GPX/TBARS) was significantly lower in the preeclamptic patients than in the pregnant controls (p<0.0001). There were no statistically significant differences in the homocysteine level, the TBARS levels, the GPX activity, the gestational age, and birth weight between the wild type of GPX polymorphism and the variant type of GPX polymorphism (p>0.05). After controlling for the covariates, homocysteine reduced the gestational age (p=0.0035) and reduced the birth weight by 27 g (p=0.0259). CONCLUSION: The levels of the oxidative stress markers (homocysteine and TBARS) are higher and the antioxidant capacity (GPX/TBARS) is lower in preeclampsia patients. Homocysteine significantly reduces the fetal growth rate.
Key Words: Homocysteine, TBARS, GPX activity, Preeclampsia, Oxidative stress, Birth weight
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