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Korean Journal of Obstetrics & Gynecology 2004;47(4):748-751.
Published online April 1, 2004.
Delivery in a Patient with Paroxysmal Nocturnal Hemoglobinuria Successfully Managed with Low Molecular Weight Heparin Therapy.
Ho Bin Kim, Hye Jin Chang, Jeong In Yang, Haeng Soo Kim, Hee Sug Ryu, Hyo Chul Kim
1Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.
2Department of Hemato-Oncology, Ajou University School of Medicine, Suwon, Korea.
Abstract
Paroxysmal nocturnal hemoglobinura is a very rare acquired clonal hematopoietic cell disorder leading to chronic intravascular hemolysis caused by abnormal complement activation. Pregnancy in a patient with paroxysmal nocturnal hemoglobinuria is often complicated with thrombosis resulting serious materno-fetal morbidity and mortality. A case of successful maintenance of the pregnancy, delivery and postpartum in a woman at gestational age of 37 weeks and 2 days with paroxysmal nocturnal hemoglobinuria managed with prophylactic transfusions and anticoagulation therapy by low molecular weight heparin is presented with a review of literature.
Key Words: Paroxysmal nocturnal hemoglobinuria, Low molecular weight heparin, Pregnancy
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