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Korean Journal of Obstetrics & Gynecology 2004;47(6):1171-1178.
Published online June 1, 2004.
Expression of Angiopoietin-1 and Angiopoietin-2 mRNA in Eutopic and Ectopic Endometrium.
Ji Young Lee, Seong Soo An, Byung Il Yun, Sung Eun Hur, In Sook Sohn, Soo Nyung Kim
1Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.
2Department of Obstetrics and Gynecology, College of Medicine, Ewha Woman's University, Seoul, Korea.
Abstract
OBJECTIVE
To investigate the mRNA expression of Angiopoietin (Ang)-1 and Ang-2 in ectopic and eutopic endometrium from women with or without endometriosis throughout the menstrual cycle. METHODS: Total RNA was extracted and reverse transcribed into cDNA. The expression of Ang-1 and Ang-2 was examined by quantative competitive PCR (QC PCR) and each result was analyzed by Kruskal- Wallis analysis and Mann-Whitney U-test. RESULTS: The expression of Ang-1 mRNA was statistically significantly higher in endometrium of follicular phase from women with endometriosis compared to that from normal ones in the follicular phase. Endometriotic tissues expressed significantly lower Ang-2 mRNA compared to endometrium from women without endometriosis. CONCLUSION: We suggested that the expression of Ang-1 mRNA could be associated with the pathogenesis of endometriosis and might have a role as neovascularizaton and survival of ectopic endometrium.
Key Words: Endometriosis, Angiopoietin-1, Angiopoietin-2


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