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Korean Journal of Obstetrics & Gynecology 2004;47(7):1376-1384.
Published online July 1, 2004.
Affecting Factors of Outcome of CC/hMG Ovarian Stimulation and Intrauterine Insemination.
Yun Seok Yang, Jang Ok Park, Kwan Young Oh, Byung Kwan Lee, Joon Sook Park, Jin Yong Lee
1Department of Obstetrics and Gynecology, Eulji University School of Medicine, Daejeon, Korea.
2Infertility Research Center, Eulji University School of Medicine, Daejeon, Korea.
Abstract
OBJECTIVE
We have attempted to identify prognostic factors regarding CC/hMG ovarian stimulation and IUI in infertility and to seek factors valuable in planning infertility treatment and predicting the success rate of IUI therapy in individual couples. METHODS: The variables selected for initial analysis were female age, duration of infertility, type and diagnosis of infertility, number of pre-ovulatory follicles (>or=16 mm, >or=18 mm follicles), thickness of the endometrium, number of the treatment cycles, result of semen analysis, ovarian stimulation protocol, number of IUI. A logistic regression method was used to identify significant variables that contribute to the success of CC/hMG/IUI treatment. RESULTS: Logistic regression analysis revealed four predictive variables as regards pregnancy: duration of infertility (p=0.011), infertility etiology (p=0.049), number of IUI (p=0.004), method of ovarian stimulation (p=0.042). A cause of infertility, especially ovarian dysfunction other than tubal factor, a shorter duration of infertility (<6 years) and CC/hMG minimal ovarian stimulation protocol with double IUI resulted in better treatment success in CC/hMG with IUI cycles. CONCLUSION: We concluded that careful patient selection criteria coupled with successful ovarian stimulation and increased sperm count in female reproductive tract is the model for CC/hMG/IUI sucess.
Key Words: Infertility, CC/hMG ovarian stimulation, IUI, Pregnancy


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