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Korean Journal of Obstetrics & Gynecology 2004;47(8):1492-1499.
Published online August 1, 2004.
Vascular Endothelial Growth Factor and Angiopoietin-1 and -2 mRNA Expressions in Invasive Cervical Carcinoma.
Han Moie Park, Hye Won Chung, Jung Ja Ahn, Seung Cheol Kim, Hye Sung Moon
1Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans' University, Seoul, Korea.
2Department of Obstetrics and Gynecology, College of Medicine University of Ulsan, Asan Medical Center, Kangnung, Korea.
Abstract
OBJECTIVE
This study was aimed to investigate the vascular endothelial growth factor (VEGF) mRNA and angiopoietin (Ang) -1 and -2 mRNA expressions between cervical cancer and normal cervix, and to assess the relationships among their expression and other prognostic factors of invasive cervical cancer. METHODS: The tissues were obtained from 34 patients with cervical cancer and 14 patients with normal cervix undergoing hysterectomy. Total RNA was extracted and reverse transcribed into cDNA. RT-PCR and QC-PCR was performed to evaluate VEGF and Ang-1 and -2 mRNA expressions. Clinicopathologic factors of cervical cancer were reviewed with the patient's charts and results were analyzed with Mann-Whitney U test, Spearman correlation test and logistic regression analysis. RESULTS: VEGF, Ang-1 and -2 mRNA expression in cervical cancer was higher than that in normal cervix (p<0.05) and there were significant correlations between Ang-2 mRNA expression and VEGF mRNA expression in all stage of cervical cancer (p<0.05). A definite correlation was found between VEGF mRNA expression and clinical stage, SCC-Ag levels, lymph node metastasis of cervical cancer (p<0.05). Also, There was significant correlation among Ang-2 mRNA expression and clinical stage, tumor sizes, SCC-Ag levels, lymph node metastasis of cervical cancer (p<0.05). Ang-1 mRNA expression was significantly correlated with clinical stage of cervical cancer (p<0.05). CONCLUSION: The expression of VEGF mRNA, Ang-1 and -2 mRNA could be associated with the progression and metastasis of cervical cancer and might have a role as prognostic parameters in cervical cancer.
Key Words: VEGF, Ang-1 and -2, Invasive cervical cancer


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