p53 Codon 72 Polymorphism in Patients with Endometriosis.

Kang, Kyoung Hwa; Choi, Young Min; Lee, Byung Soek; Kang, Soon Beom; Chang, Eun Ran; Bae, Sang Kyu; Park, In Ae; Jun, Jong Kwan; Jee, Byung Chul; Ku, Seung Yup; Suh, Chang Suk; Kim, Seok Hyun; Kim, Jung Gu; Moon, Shin Yong

Obstet Gynecol Sci > Volume 47(8); 2004 > Article

Original Article

Korean Journal of Obstetrics & Gynecology 2004;47(8):1540-1544.
Published online August 1, 2004.

p53 Codon 72 Polymorphism in Patients with Endometriosis.

Kyoung Hwa Kang, Young Min Choi, Byung Soek Lee, Soon Beom Kang, Eun Ran Chang, Sang Kyu Bae, In Ae Park, Jong Kwan Jun, Byung Chul Jee, Seung Yup Ku, Chang Suk Suh, Seok Hyun Kim, Jung Gu Kim, Shin Yong Moon

¹Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
²Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Korea.
³Medical Research Center, Department of Pathology, Seoul National University College of Medicine, Korea.
⁴Department of Obstetrics and Gynecology, Eulji University College of Medicine, Korea.
⁵Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Korea.

Abstract

OBJECTIVE
To explore the association of p53 codon 72 polymorphism with endometriosis. METHODS: Two hundred seventy-one women with surgically or histologically diagnosed edometriosis of stage I-IV, and 219 patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. Allele frequencies and genotype distribution of p53 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity) in affected women and controls were evaluated. RESULTS: The genotype distributions of p53 codon 72 polymorphisms did not differ significantly between endometriosis group and control group (p=0.086). However, the genotype distributions of p53 codon 72 polymorphisms differ significantly between stage I-II endometriosis group and control group (p=0.043). Proline homozygotes had higher risk for stage I-II endometriosis compared to arginine homozygotes (odds ratio=2.75, p=0.013). CONCLUSION: These results suggest that proline homozygote of p53 codon 72 polymorphism is associated with the risk of minimal or mild stage of endometriosis in the Korean population.

Key Words: Endometriosis, p53, Polymorphism, Proline, Arginine