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Korean Journal of Obstetrics & Gynecology 2004;47(8):1552-1557.
Published online August 1, 2004.
Estrogen Receptor Gene Polymorphism (PvuII and XbaI) and Outcomes of Controlled Ovarian Hyperstimulation for In-vitro Fertilization and Embryo Transfer.
Kyu Ri Hwang, Young Min Choi, Ji Sung Yoon, Won Don Lee, Seung Yup Ku, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Jung Gu Kim, Shin Yong Moon
1Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Korea.
2Institute of Reproductive Medicine and Population, Medical Research Center, College of Medicine, Seoul National University, Korea.
3Seoul Maria Hospital, Korea.
4Department of Obstetrics and Gynecology, Seoul National University, Boramae Hospital, Seoul, Korea.
Abstract
OBJECTIVE
The purpose of this study was to investigate the association of the estrogen receptor alpha gene polymorphism (PvuII and XbaI) with outcomes of controlled ovarian hyperstimulation for in- vitro fertilization and embryo transfer (IVF-ET). METHODS: The PvuII and XbaI in the estrogen receptor gene was analyzed by PCR-RFLP in 189 infertile women undergoing controlled ovarian hyperstimulation for in-vitro fertilization and embryo transfer. Comparisons were done between the three PvuII or XbaI genotypes, concerning the numbers of follicles and oocytes, the ratio of oocytes to follicles, serum estradiol concentrations, total dose of gonadotropins, number of transferred embryos, implantation rate and pregnancy rate. RESULTS: In this study, there was no statistically significant difference in outcomes of controlled ovarian hyperstimulation, except total dose of gonadotropins used among three genotypes of PvuII or XbaI polymorphism. CONCLUSION: These results suggest that the PvuII and XbaI polymorphisms of the estrogen receptor gene are not associated with the outcomes of controlled ovarian hyperstimulation for IVF-ET in Korean infertile women.
Key Words: Estrogen receptor, Polymorphism, In-vitro fertilization and embryo transfer (IVF-ET), Controlled ovarian hyperstimulation


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