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Korean Journal of Obstetrics & Gynecology 2004;47(10):1949-1953.
Published online October 1, 2004.
Effect of Metformin Treatment and Insulin Resistance in Patients with Polycystic Ovary Syndrome.
Kyu Ri Hwang, Young Min Choi, Doo Seok Choi, Kwang Hyun Baek, Hye Won Jeon, Kwang Bum Bae, Young Soo Son, Seung Yup Ku, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Jung Gu Kim, Shin Yong Moon
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
2Institute of Reproductive Medicine and Population, Seoul National University College of Medicine, Seoul, Korea.
3Department of Obstetrics and Gynecology, Seoul National University Boramae Hospital, Korea.
4Department of Obstetrics and Gynecology, Sungkyunkwan University School of Medicine, Korea.
5Department of Obstetrics and Gynecology, Pochon CHA University College of Medicine, Korea.
6Department of Obstetrics and Gynecology, Cheongju St. Mary Hospital, Cheongju, Korea.
Abstract
OBJECTIVE
This study was performed to investigate the effect of metformin treatment and insulin resistance in the patients with polycystic ovary syndrome. METHODS: Twenty three patients with polycystic ovary syndrome were included at Seoul National University Hospital from September 2001 to September 2003. Metformin was administered at daily 1,500 mg for 3 months to these patients. Then restoration of regular menstruation or recovery of ovulation was evaluated and insulin resistance was compared between the responder and the non-responder before and after metformin treatment. RESULTS: Eleven patients (47.8%) showed a significant improvement in menstrual or ovulation cyclicity whereas twelve patients had no change. There was no statistically significant difference in the insulin resistance between the responder and the non-responder before and after metformin treatment. CONCLUSION: In non-obese patients with polycystic ovary syndrome, metformin treatment seems to be effective to improvement of menstrual or ovulation cyclicity irrespective of insulin resistance expressed as glucose-to- insulin ratio and HOMA.
Key Words: Polycystic ovary syndrome, Insulin resistance, Metformin


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