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Korean Journal of Obstetrics & Gynecology 2004;47(12):2308-2312.
Published online December 1, 2004.
Expression of Aquaporin-8 in Placenta of Preeclampsia.
Min Sook Ha, Tae Gi Hwang, Sang Kyeong Lee, In Ha Lee, Seung Hwa Hong, Yeon Jin Park, Eun Hwan Jeong, Hak Soon Kim
Department of Obstetrics and Gynecology, Chungbuk National University Hospital, Cheongju, Korea.
This study was to determine whether aquaporin-8, which plays a role as a transcellular water channel, is expressed in human placenta, and to compare the degree of its expression between preeclamptic women and normal pregnant women. METHODS: Placentas were obtained from severely preeclamptic women and normal pregnant women who were delivered babies by cesarean section before the onset of labor in the Chungbuk National University Hospital. In situ hybridization with aquaporin-8 cRNA probe was performed using paraffin-embedded tissue section. Signal of aquaporin-8 expression was observed with light microscope. RESULTS: In situ hybridization demonstrated strong expression of aquaporin-8 mRNA in the placentas of both preeclamptic women and normal pregnant women. The degree of expression was the same in both group. CONCLUSION: Aquaporin-8 in human placenta may not be related to the pathogenesis of preeclampsia.
Key Words: Preeclampsia, Aquaporin-8, In situ hybridization

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