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Korean Journal of Obstetrics & Gynecology 2004;47(12):2380-2383.
Published online December 1, 2004.
The association of serum CA-125 level and severity of dysmenorrhea with lesion depth in adenomyosis.
Seog Hyun Jang, Tae Soon Ann, En Sung Oh, Jae Hag Sim, Ae Lan Paik, Jong Cheon Weon, Kang Woo Jung, Yong Pil Kim
1Department of Obstetrics and Gynecology, Pohang Saint Mary's Hospital, Pohang, Korea.
2Department of Pathology, Pohang Saint Mary's Hospital, Pohang, Korea.
To evaluate the association of level of CA-125 and severity of dysmenorrhea with lesion depth in adenomyosis. METHODS: Sixty-eight women who had undergone hysterectomy and were found to have pure adenomyosis on histopathologic examination were reviewed retrospectively. Specimens were stratified according to the degree of adenomyosis penetration into 4 groups: group A consisted of specimens with adenomyosis penetration into myometrium of up to 25%; group B, 26-50%; group C, 51-75%, and group D, >75%. All women were submitted to serum determination of CA-125. Severity of dysmenorrhea was assessed by means of a modification of 10-point verbal rating scale. RESULTS: Each group was not correlated with severity of dysmenorrhea (p=0.7394 Fisher's exact test). The means of serum CA-125 levels was increased corresponding to depth of adenomyosis (p=0.0441 ANOVA test). CONCLUSION: In this study, serum CA-125 level is associated with the depth lesion and severity of dysmenorrhea is not. Therefore, the level of serum CA-125 might be useful indicator in management of adenomyosis before surgery.
Key Words: Adenomyosis, Dysmenorrhea, CA-125

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