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Korean Journal of Obstetrics & Gynecology 2004;47(12):2403-2048.
Published online December 1, 2004.
The Pattern of Fhit and p53 Expression in Cervical Intraepithelial Neoplasm and Invasive Cervical Cancer.
Seon Ha Joo, Na Hye Myong, Jin Wan Park
1Department of Obstetrics and Gynecology, College of Medicine, Dan-Kook University, Cheonan, Korea.
2Department of Pathology, College of Medicine, Dan-Kook University, Cheonan, Korea.
Abstract
OBJECTIVE
To evaluate Fragile histidine triad (Fhit) and p53 expression pattern in cervical intraepithelial neoplasm (CIN) and invasive cervical cancer, and to verify the correlation between the loss of Fhit and clinicopathological parameters of invasive cervical carcinoma and the relationship between Fhit and p53 expression. METHODS: 10 low-grade squamous intraepithelial lesions (LSIL), 16 high-grade squamous intraepithelial lesions (HSIL), and 21 invasive cervical carcinomas were evaluated by immunohistochemical staining for Fhit and p53 primary antibody. Their expression patterns in CIN and invasive cervical cancer were analysed semiquantitatively as positive and negative by the staining area and intensity. Clinicopathological data were obtained by review of patients' hospital records. RESULTS: Compared with CIN (LSIL and HSIL), invasive cervical carcinoma showed significantly loss of Fhit expression (p<0.05). P53 expression did not show the significant difference between CIN and invasive cervical cancer. There was no relationship between loss of Fhit and p53 expression in CIN and invasive cervical cancer. But loss of Fhit expression in invasive cervical cancer was also significantly associated with FIGO stage (p<0.05). CONCLUSION: Our results suggest that loss of Fhit expression may play an important role in the malignant transformation of CIN to invasive cancer. However, further molecular studies are needed to elucidate the role of Fhit gene in the carcinogenesis of cervical cancer.
Key Words: Fhit, p53, LSIL, HSIL, Invasive cervical cancer


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