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Korean Journal of Obstetrics & Gynecology 2004;47(12):2430-2438.
Published online December 1, 2004.
The relationship between calcium sensing receptor gene (CA) polymorphism, bone mineral density and bone responsiveness to hormone replacement therapy in postmenopausal Korean women.
Jung Gu Kim, Seung Yup Ku, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim, Young Min Choi, Shin Yong Moon
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
OBJECTIVE
To evaluate the relationship between the calcium sensing receptor (Casr) gene cytosine adenine (CA) polymorphism, bone mineral density (BMD) and bone responsiveness to hormone replacement therapy (HRT). METHODS: Casr (CA) polymorphism was analyzed by polyacrylamide-urea gel electrophoretic patterns, genescan and direct DNA sequencing in 502 postmenopausal Korean women. Among these women, 352 women received sequential HRT for 1 year. Serum bone alkaline phosphatase, CrossLaps, osteocalcin, calcitonin, and parathyroid hormone levels were measured by immunoassay and Serum calcium and phosphorus levels by atomic absorptiometry. BMD at the lumbar spine and proximal femur was determined by dual energy X-ray absorptiometry before and after HRT of 1 year. RESULTS: Nine Casr alleles were observed with product sizes ranging between 176-196 bp, and their distribution was as follows: 188 bp 26.2%, 194 bp 19.8%, 186 bp 18.2%, 190 bp 15.5%. 192 bp 14.3% etc. BMD at the Ward's triangle was significantly lower in women carrying at least one copy of 216 bp Casr (CA) allele than in women who did not this allele, but no significant differences in annual percentage changes of BMD were noted among Casr (CA) genotypes. There were no significant differences in after HRT levels of biochemical bone markers and their 6 month percentage changes after HRT among Casr (CA) genotypes. The Casr (CA) genotypes were not distributed differently between HRT-responders and HRT-nonresponders (women who lose more than 3% of bone mass per year) or between women with normal BMD and women with low bone mass. CONCLUSION: The Casr (CA) polymorphism is not associated with bone responsiveness to HRT but BMD of Ward's triangle in Korean women.
Key Words: Postmenopausal women, Casr, (CA) gene polymorphism, BMD, HRT


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