Two Cases of Uterine Papillary Serous Carcinoma.

Kim, Ju Kyoung; Chang, Bo Seung; Kim, Seung Chan; Yun, Young Eun; Park, Ok Rang; Son, Kyoung Rak

Case Report

Korean Journal of Obstetrics & Gynecology 2004;47(12):2499-2505.
Published online December 1, 2004.

Two Cases of Uterine Papillary Serous Carcinoma.

Ju Kyoung Kim, Bo Seung Chang, Seung Chan Kim, Young Eun Yun, Ok Rang Park, Kyoung Rak Son

¹Department of Obstetrics and Gynecology, Daegu Fatima Hospital, Daegu, Korea.
²Department of Pathology, Daegu Fatima Hospital, Daegu, Korea.

Abstract

Uterine papillary serous carcinoma (UPSC) behave more aggressively than other endometrial carcinomas and have a propensity for intraabdominal spread, simulating the behavior of ovarian carcinoma. Because of high relapsing rate, and high mortality rate of UPSC, many gynecologist studied about its treatment regimen and recommended many treatment method. Many investigators recommended that patients with UPSC should undergo a staging laparotomy and they suggested the surgery should include at least total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, pelvic lymphadenectomy, paraaortic lymphadenectomy, peritoneal washing and peritoneal cytology, By and large, adjuvant systemic Platinum based chemotherapy or, paclitaxel based chemotherapy and adjuvant whole abdominal irradiation or pelvic irradiation was prescribed. We experienced two cases of the UPSC stage IIIc and stage IV diagnosed after explolaparotomy. We present these cases and review the literatures about the optimal treatment regimen of UPSC.

Key Words: UPSC, Laparotomy, Chemotherapy, Irradiation