Korean J Obstet Gynecol Search

CLOSE


Korean Journal of Obstetrics & Gynecology 2005;48(2):418-427.
Published online February 1, 2005.
Survivin and Bcl-2 expression in eutopic endometrium with and without endometriosis.
Yun Jin Kim, Young Ah Kim, Han Seong Kim, Woon Hee Suh, Kyung Koo Kim, Doo Young Chang, Myung Kwon Jeon, Eung Soo Lee
1Department of Obstetrics and Gynecology, College of Medicine, Inje University, Ilsan Paik Hospital, Kyunggi, Korea. camanbal@ilsanpaik.ac.kr
2Department of Pathology, College of Medicine, Inje University, Ilsan Paik Hospital, Kyunggi, Korea.
Abstract
OBJECTIVE
To examine expression of survivin and Bcl-2 in eutopic endometrium with endometriosis and without endometriosis by immunohistochemical stain. METHODS: Expression of survivin and Bcl-2 was immunohistochemically investigated in eutopic endometrium with endometriosis (n=30, study group I; laparoscopy-proved endometriosis, study group II; adenomyosis) or without endometriosis (n=34, control group). The score of immunohistochemical staining was evaluated semi-quantitative method modified by Sinicrope and Lu. Statistical analyses was carried out using one-way ANOVA with Turkey test. RESULTS: Survivin expression was significantly higher in nucleus of glandular epithelium of eutopic endometrium with endomtriosis compared to that without endometriosis (p<0.05). Increased expression of Bcl-2 was found in glandular epithelium of eutopic endometrium with endometriosis than without endometriosis, but there was no significantly difference. CONCLUSION: Our findings suggest that increased survivin expression may contribute to survival of endometriosis. Moreover, survivin could play an important role in pathogenesis of endometriosis.
Key Words: Endometriosis, Eutopic endometrium, Survivin, Bcl-2


ABOUT
ARTICLE & TOPICS
Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES
POLICY
FOR CONTRIBUTORS
Editorial Office
4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea
Tel: +82-2-3445-2382    Fax: +82-2-3445-2440    E-mail: journal@ogscience.org                

Copyright © 2021 by Korean Society of Obstetrics and Gynecology.

Developed in M2PI

Close layer
prev next