The effects of Raloxifene therapy on endometrium in postmenopausal women.

Kim, Gwang Jun; Park, Hyoung Moo

Obstet Gynecol Sci > Volume 48(4); 2005 > Article

Original Article

Korean Journal of Obstetrics & Gynecology 2005;48(4):962-968.
Published online: April 1, 2005

The effects of Raloxifene therapy on endometrium in postmenopausal women.

Gwang Jun Kim, Hyoung Moo Park

Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University, Seoul, Korea. hmpark@hananet.net

Abstract

OBJECTIVE
To determine the effects of a selective estrogen receptor modulator (SERM), raloxifene, on endometrium in postmenopausal women. METHODS: Double-blind randomized controlled study was designed for 138 healthy postmenopausal women to determine the effects of raloxifene on postmeonopausal endometrium. The women were randomly assigned to receive either placebo, or raloxifene HCl 60 mg/day for 6 months. Transvaginal ultrasound was done at baseline and at 6 months later. RESULTS: Mean endometrial thickness of normal postmenopausal women was 3.4 ( +/- 1.6) mm. Mean endometrial thickness was decreased by 0.2 mm in both groups, but with no statistical significance. CONCLUSION: Raloxifene 60 mg/day did not stimulate the endometrium after 6 months of use in postmenopausal women.

Keywords: Raloxifene; Endometrium; Postmenopause