| Clinical analysis of Paclitaxel and Platinum in Recurrent Carcinoma of the Uterine Cervix. |
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Seung Wook Jeon, Young Tak Ju, Ji Hyeon Kim, Ok Joo Ahn, Young Moon, Kwang Beom Lee, Jin Woo Shin, Jong Min Lee, Chan Yong Park |
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Department of Obstetrics and Gynecology, Gachon Medical School, Inchon, Korea. mjb307@hanmail.net |
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| Abstract |
OBJECTIVE
This study was performed to evaluate the efficacy and the toxicity of paclitaxel and platinum in patients with recurrent cervical carcinoma. METHODS: Twenty nine patients were treated with paclitaxel 135-175 mg/m2 and cisplatin 50-75 mg/m2 or carboplatin at AUC 5 every 3 weeks for a maximum of six courses from January 2001 to January 2004. RESULTS: A total 134 cycles with paclitaxel and platinum were administered. Ten patients (34.2%) achieved an objective response, including four complete responses (13.6%) and six partial responses (20.6%). Overall survival was 13.2 months, and the response and non-response group were 23.2 and 8.1 months, respectively (p=0.01). Clinical response according to recurrent site was significantly different (p=0.048) but, survival was not (p=0.22). Grade 3 or 4 granulocytopenia in 75.9% of patients was developed and one expired due to neutropenic sepsis after first cycle chemotherapy. CONCLUSION: The combination of paclitaxel and platinum seems relatively well tolerated and has 34.2% response rate in patients with recurrent cervical cancer. Further study for this combination chemotherapy and prognostic factor should be needed. |
| Key Words:
Recurrent, Cervical cancer, Paclitaxel, Platinum |
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