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Korean Journal of Obstetrics & Gynecology 2005;48(9):2067-2072.
Published online September 1, 2005.
Evaluation of prevention program for neonatal vertical transmission from HBsAg positive mother in Korea.
Bo Wook Kim, Kyung Seo, Sook Kyoung Park, Young Tak Kim, Ok Park, Hyun Joon Lee, Won Ki Hong, Han Sung Whang
1Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. kyungseo@yumc.yonsei.ac.kr
2Vaccine Preventable Disease Control and National Immunization Program Division, Korea Center for Disease Control and Prevention (KCDC), Korea.
3Infectious Disease Surveillance Division, Korea Center for Disease Control and Prevention (KCDC), Korea.
Abstract
OBJECTIVE
For evaluation of prevention program for neonatal vertical transmission from HBsAg positive mother in Korea METHODS: From January 15th to February 15th 2003, the status of neonatal vaccination, immunoglobuline injection and breast feeding of HBsAg positive mother was evaluated by using mailed questionnaire in 848 hostpitals with more than 100 deliveries in the year of 2001. 341 out of 848 (40.2%) hospitals returned questionnaires. RESULTS: 91.9% of total hospital reported that the vaccination of hepatitis B and immunoglobulin injection was done within 12 hours after birth in more than 90% of neonate. The most commonly used vaccine type was 0-1-6 method. In case of unknown result of HBsAg/ HBsAb in mother, 84.4% of hospitals delayed immunoglobulin injection until complete report, however 63% of hospitals gave hepatitis vaccine without delay before complete result. The breast feeding of HBsAg positive mother was recommended according to the result of HBeAg in 66.3% of hospitals while 24.9% of hospitals recommend breast feeding. CONCLUSION: Most hospitals in Korea reported that vaccination of Hepatitis B and immunoglobulin injection was done within 12 hours after in over 90% of neonate whose mother was HBsAg Positive. But continuous education and careful monitoring are required for injection method and vaccination policy in neonates of mothers with unknown result of HBsAg/HBsAb of mother.
Key Words: Vertical transmission, HBsAg positive mother, Neonatal immunization, Breast feeding
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