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Korean Journal of Obstetrics & Gynecology 2005;48(9):2112-2118.
Published online September 1, 2005.
Comparison of diagnostic methods used for detection of preterm premature rupture of membrane.
In Yang Park, Hyun Sun Ko, Youn Hee Kim, Hee Joong Lee, Chan Joo Kim, Dae Young Chung, Soo Pyung Kim, Chang Yi Kim, Jong Chul Shin
Department of Obstetrics and Gynecology, College of Medicine, Catholic University of Korea. jcshin@catholic.ac.kr
The purpose of this study is to compare the detection rate among diagnostic methods used for preterm premature rupture of membrane (PPROM). METHODS: The study population was composed of pregnant women who visited delivery room at our hospital due to vaginal watery discharge from 1 March 2002 to 28 February 2003. The gestational age was between 15 and 36+6/7 weeks of gestation. The study group was composed of 74 pregnant women. The rupture of membrane was tested by nitrazine test, ROM-check test and actim PROM test. It was regarded true positive that normal spontaneous preterm delivery was occurred within 72 hrs. The detection rates of each test were analyzed. RESULTS: There were positive results in 65 cases of nitrazine test, 23 cases of ROM-check test and 53 cases of actim PROM test. Of these positive cases, cases that delivered within 72 hours were in 33 cases of nitrazine test, 13 cases of ROM-check test and 30 cases of actim PROM test. Among three diagnostic methods, the sensitivity is highest for nitrazine test (86.8%) and the specificity is highest for ROM- check test (72.2%). The positive predictive value shows no significant difference among three methods and the negative predictive value is highest for actim PROM test (61.9%). The combination of ROM-check test and actim PROM test shows most accurate detection rates for diagnosis of preterm premature rupture of the membranes (sensitivity 84.2%, specificity 42.3%, positive predictive value 56.1%, negative predictive value 64.7%). CONCLUSION: Our data shows that combination of diagnostic methods might improve detection rate for PPROM. Future studies remain to improve detection rate of PPROM.
Key Words: Preterm premature rupture of membrane, Nitrazine test, ROM-check test, Actim PROM test

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